@article{10223,
  keywords = {Antigens, Bacterial, Cell Transformation, Viral, Cells, Cultured, Clone Cells, Cytotoxicity, Immunologic, Herpesvirus 4, Human, Humans, leprosy, Lymphocyte Activation, Mycobacterium, Mycobacterium leprae, Species Specificity, T-Lymphocytes},
  author = {Launois P and Shankar P and Wallach D and Flageul B and Cottenot F and Bach M A},
  title = {Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients.},
  abstract = {<p>T-cell clones capable of mounting a proliferative response to Mycobacterium leprae were obtained in three leprosy patients (two polar lepromatous and one polar tuberculoid) either from M. leprae-activated or from protein-purified derivative-activated polyclonal T lymphoblasts. All these clones expressed the CD4 surface marker. Some of them proliferated to the antigen only in the presence of interleukin-2. A majority expressed cross-reactive responses to other mycobacteria. Clones obtained from the lepromatous patients did not differ in any of these features from those obtained from the tuberculoid patient. M. leprae-reactive clones obtained from one lepromatous patient displayed strong antigen-specific cytotoxicity toward autologous antigen-coated target cells. This phenomenon was not observed for any clone of the other lepromatous patient and was seen only for one clone in the tuberculoid patient.</p>},
  year = {1987},
  journal = {Annales de l'Institut Pasteur. Immunology},
  volume = {138},
  pages = {723-35},
  month = {1987 Sep-Oct},
  issn = {0769-2625},
  doi = {10.1016/s0769-2625(87)80027-2},
  language = {eng},
}