@article{10129,
  keywords = {Drug Therapy, Combination, Humans, Isoniazid, Isonicotinic Acids, leprosy, Prothionamide, Sulfamethoxazole, Trimethoprim},
  author = {Freerksen E and Rosenfeld M and Spannuth G},
  title = {New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid.},
  abstract = {<p>Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide + DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years. The present paper describes the attempts made to find solutions to these problems. With two new combinations, alternatives have become available, and the average treatment time is shortened to 6 months. Both combinations are also effective in tuberculosis.</p>},
  year = {1989},
  journal = {Chemotherapy},
  volume = {35},
  pages = {133-9},
  month = {1989},
  issn = {0009-3157},
  doi = {10.1159/000238660},
  language = {eng},
}