@article{100964,
  keywords = {Nuclear Factor , Kappa Beta (NF-κB) Pathway, Cytokine Cascade, Potential Therapeutic Target, Leprosy},
  author = {Chakraborty D and De A and Hena A},
  title = {54750 A Cross-Sectional Study to Evaluate the Role of the Nuclear Factor Kappa Beta (NF-κB) Pathway in Regulating the Cytokine Cascade and as a Potential Therapeutic Target in Leprosy},
  abstract = {<p>Pattern recognition receptors (PRR), such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) found in microorganisms but not hosts, allow Leprae bacilli to be recognized as foreign. Sen and Baltimore discovered the transcription factor nuclear factor kappa-B (NF-B), employed by eukaryotic cells to regulate immunity, cell differentiation, and proliferation. This study aimed to evaluate the role of the nuclear factor kappa B (NF-B) pathway in controlling the cytokine cascade in leprosy due to a lack of understanding of the link between cytokines and the severity of leprosy.</p>
},
  year = {2024},
  journal = {Journal of the American Academy of Dermatology},
  volume = {91},
  publisher = {Elsevier BV},
  issn = {0190-9622},
  doi = {10.1016/j.jaad.2024.07.418},
  language = {ENG},
}