@article{10082,
  keywords = {Adult, Dapsone, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Lepromin, leprosy, Male, Recurrence, Rifampin},
  author = {Katoch K and Ramanathan U and Natrajan M and Bagga A K and Bhatia A S and Saxena R K and Ramu G},
  title = {Relapses in paucibacillary patients after treatment with three short-term regimens containing rifampin.},
  abstract = {<p>Three multidrug regimens all containing rifampin and dapsone have been tried for the treatment of 278 cases of paucibacillary leprosy. Regimen I was the one recommended by the WHO Study Group. Regimen II was the same as Regimen I with depsone alone continued for a further 6 months. Regimen III was the same as Regimen II but rifampin was given daily for the first 7 days. The patients were comparable with regard to disease classification, lepromin status, bacteriological status, and number of lesions. As reported earlier, the disease inactivity rates by 1 year of treatment were much greater with Regimens II and III than with Regimen I (94% and 97% vs 76%). Early reaction was seen in 6% of those in Regimen III and in none in Regimens I and II. Late reaction was observed in 9% of those in Regimen I and none in Regimens II and III. During 3 1/2 years of follow up, 13% of the cases in Regimen I, 1% in Regimen II, and 2% in Regimen III relapsed. Since the patients in the three regimens were otherwise comparable, it is concluded that the high inactivity rate, low relapse rate (1%-2%), and no early or late reaction as observed in Regimen II patients were because of adequate treatment.</p>
},
  year = {1989},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {57},
  pages = {458-64},
  month = {1989 Jun},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v57n2a02.pdf},
  language = {eng},
}