Molecular drug susceptibility testing and genotyping of Mycobacterium leprae from South America.
| Title | Molecular drug susceptibility testing and genotyping of Mycobacterium leprae from South America. |
| Publication Type | Journal Article |
| Authors | Singh P, Busso P, Paniz-Mondolfi A, Aranzazu N, Monot M, Honore N, de Belone AF, Virmond M, Villarreal Olaya ME, Rivas C, Cole ST |
| Journal | Antimicrobial agents and chemotherapy |
| Year of Publication | 2011 |
| Publication Language | ENG |
| Abstract | Possible drug resistance in Mycobacterium leprae from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%) and 4O (1.7%). |
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